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Hypoglycemic effects of a Fructus Mori polysaccharide in vitro and in vivo

Chun Chen1, Qiang Huang, Chao Li

  • 1College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China. lfxfu@scut.edu.cn.

Food & Function
|June 27, 2017
PubMed

Insights

Mulberry fruit polysaccharide (MFP) demonstrates significant hypoglycemic and antioxidant effects. This natural compound helps lower blood glucose and protect against organ damage in diabetic mice.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Natural Product Chemistry

Background:

  • Mulberry fruit polysaccharide (MFP) is a key bioactive component of mulberry fruit.
  • MFP exhibits various beneficial bioactivities.
  • Diabetes mellitus is a metabolic disorder characterized by hyperglycemia.

Purpose of the Study:

  • To investigate the hypoglycemic and antioxidant properties of MFP.
  • To evaluate the protective effects of MFP on streptozotocin (STZ)-induced diabetic mice.

Main Methods:

  • In vitro experiments assessed insulin secretion and pancreatic β cell proliferation.
  • In vivo studies involved oral administration of MFP to STZ-induced diabetic mice.
  • Biochemical assays measured malondialdehyde (MDA) levels and antioxidant enzyme activities (SOD, GPx, CAT).
  • Histopathological examination assessed tissue damage in pancreas, liver, and kidney.

Main Results:

  • MFP significantly increased insulin secretion and promoted pancreatic β cell proliferation in vitro.
  • Oral MFP administration reduced blood glucose levels and promoted weight loss in diabetic mice.
  • MFP decreased MDA levels and increased SOD, GPx, and CAT activities in the liver.
  • Histopathology revealed that MFP alleviated pancreatic, liver, and kidney tissue damage.

Conclusions:

  • MFP possesses significant hypoglycemic and antioxidant properties.
  • MFP offers protective effects against STZ-induced diabetes in mice.
  • MFP shows potential as a therapeutic agent for managing diabetes.

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