Signaling coupled epigenomic regulation of gene expression

Area of Science:

• Molecular Biology
• Epigenetics
• Cancer Biology

Background:

• Epigenetics governs gene expression independent of DNA sequence.
• Signaling pathways involving serine/threonine and tyrosine kinases influence epigenetic mechanisms.
• Chromatin remodeling complexes play a crucial role in regulating gene transcription.

Purpose of the Study:

• To explore the interplay between signaling kinases and chromatin remodeling factors in epigenomic regulation.
• To discuss recent advances in understanding how signaling pathways modulate gene transcription via epigenetic modifications.
• To highlight the role of these interactions in cancer cells.

Main Methods:

• Review of recent advances in signaling-dependent epigenomic regulation.
• Focus on serine/threonine and tyrosine kinases.
• Examination of their interplay with chromatin remodeling factors in cancer.

Main Results:

• Signaling kinases profoundly shape epigenetics and gene transcription.
• Post-translational modifications (PTMs) on histones and coregulators are key regulatory events.
• Interplay between PTMs and signaling pathways influences gene activity, especially in cancer.

Conclusions:

• Signaling-mediated phosphorylation of histones acts as a regulatory switch for PTMs and gene transcription.
• Kinase translocation to the nucleus integrates cytoplasmic signaling with nuclear epigenetic regulation.
• Understanding these signaling-epigenomic crosstalks is vital for cancer research.