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pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing
Koji Miki1, Kentaro Kojima, Kazuaki Oride
1Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp ohe@scl.kyoto-u.ac.jp.
Abstract:
Indocyanine green (ICG) derivatives having nucleophilic substituents were synthesized as pH-responsive near-infrared dyes. pH-responsive dyes 1-C with closed-ring structures smoothly internalized and converted to emissive open-ring structures 1-O in response to relatively low pHs in acidic intracellular compartments of HeLa cells.

