Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

775
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
775
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

52.3K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
52.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Introducing the Inaugural Early Career Board for <i>Chemical Research in Toxicology</i>.

Chemical research in toxicology·2025
Same author

Advancing Human and Environmental Safety Science Using <i>In Silico</i> Methods.

Chemical research in toxicology·2025
Same author

Which Modern AI Methods Provide Accurate Predictions of Toxicological End Points? Analysis of Tox24 Challenge Results.

Chemical research in toxicology·2025
Same author

NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.

The EMBO journal·2025
Same author

Publishing neural networks in drug discovery might compromise training data privacy.

Journal of cheminformatics·2025
Same author

Investigations into the Efficiency of Computer-Aided Synthesis Planning.

Journal of chemical information and modeling·2025

Related Experiment Video

Updated: Feb 27, 2026

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
10:27

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

12.2K

Matched Molecular Pair Analysis on Large Melting Point Datasets: A Big Data Perspective.

Michael Withnall1, Hongming Chen2, Igor V Tetko1,3,4

  • 1Helmholtz Zentrum München-German Research Center for Environmental Health, GmbH, Institute of Structural Biology, Neuherberg, Germany.

Chemmedchem
|June 27, 2017
PubMed
Summary

Matched molecular pair (MMP) analysis reveals how melting point changes correlate with functional group modifications. This scalable method accurately predicts melting point trends across large chemical datasets.

Keywords:
OCHEMgeneral solubility equationmatched molecular pairsmelting points

More Related Videos

Rapid and Efficient Zebrafish Genotyping Using PCR with High-resolution Melt Analysis
06:30

Rapid and Efficient Zebrafish Genotyping Using PCR with High-resolution Melt Analysis

Published on: February 5, 2014

23.1K
Identifying Mutations by High Resolution Melting in a TILLING Population of Rice
06:10

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice

Published on: September 2, 2019

7.8K

Related Experiment Videos

Last Updated: Feb 27, 2026

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
10:27

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

Published on: November 10, 2015

12.2K
Rapid and Efficient Zebrafish Genotyping Using PCR with High-resolution Melt Analysis
06:30

Rapid and Efficient Zebrafish Genotyping Using PCR with High-resolution Melt Analysis

Published on: February 5, 2014

23.1K
Identifying Mutations by High Resolution Melting in a TILLING Population of Rice
06:10

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice

Published on: September 2, 2019

7.8K

Area of Science:

  • Computational chemistry
  • Chemical informatics

Background:

  • Melting point (MP) is a critical physicochemical property.
  • Understanding MP determinants aids in drug design and materials science.
  • Matched Molecular Pair (MMP) analysis is a valuable cheminformatics technique.

Purpose of the Study:

  • To investigate the relationship between molecular structure and melting point changes using MMP analysis.
  • To validate and scale MMP analysis for predicting melting point variations in large compound datasets.
  • To explore the utility of MMP analysis as a privacy-preserving method for collaborative research.

Main Methods:

  • Utilized a matched molecular pair (MMP) analysis on a dataset of approximately 275,000 compounds.
  • Examined the change in melting point (ΔMP) between structurally similar molecules.
  • Correlated ΔMP with changes in functional groups and molecular descriptors like hydrogen bond donors.

Main Results:

  • Identified significant correlations between ΔMP and specific functional group changes.
  • Confirmed previously reported correlations between ΔMP and molecular descriptors.
  • Demonstrated the stability and scalability of the MMP-based method with a large and diverse dataset.

Conclusions:

  • MMP analysis is a robust and scalable method for studying melting point variations.
  • The approach effectively links molecular modifications to predictable changes in melting point.
  • MMP analysis offers a privacy-preserving framework for analyzing and sharing insights from large chemical databases.