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Updated: Feb 27, 2026

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Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
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Deproteinizing Agents as an Effective Enamel Bond Enhancer-An in Vitro Study
The Journal of Clinical Pediatric Dentistry
|June 27, 2017
Summary
Bromelain gel and sodium hypochlorite showed effective bond strength for composite resins bonded to primary teeth enamel compared to papain. Further research is needed to explore these deproteinizing agents further.
Area of Science:
- Dental Materials Science
- Biomaterials Research
- Adhesive Dentistry
Background:
- Deproteinization is a crucial step in bonding procedures.
- Evaluating novel deproteinizing agents is essential for improving bond strength.
- Primary teeth present unique challenges in restorative procedures.
Purpose of the Study:
- To compare the efficacy of different deproteinizing agents on the shear bond strength of composite resin to primary teeth enamel.
- To investigate the potential of sodium hypochlorite, papain gel, and bromelain gel as deproteinizing agents.
Main Methods:
- Forty primary molars were divided into four groups.
- Enamel was etched with phosphoric acid.
- Groups received deproteinization with sodium hypochlorite, papain gel, or bromelain gel.
- Shear bond strength was measured using a Universal Testing Machine.
Main Results:
- Mean shear bond strength was highest with bromelain gel and lowest with the control group (phosphoric acid only).
- No statistically significant differences in shear bond strength were observed between the four groups (p > 0.05).
Conclusions:
- Bromelain gel and sodium hypochlorite demonstrated effective bond strength compared to papain.
- While no significant differences were found, bromelain and sodium hypochlorite show promise as deproteinizing agents.
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