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Stereochemical formulas of beta-D-glucuronides.

K H Dudley

    Drug Metabolism and Disposition: the Biological Fate of Chemicals
    |September 1, 1985
    PubMed
    Summary

    Incorrect stereochemistry representations, particularly for beta-D-glucuronides, are increasingly common in scientific literature. Verifying chemical structures is crucial to prevent errors and ensure accurate scientific communication.

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    Area of Science:

    • Chemical structure representation
    • Scientific literature accuracy

    Background:

    • Increasing frequency of stereochemistry errors in scientific publications.
    • Specific issue of misrepresentations of beta-D-glucuronides noted in Drug Metabolism and Disposition.

    Purpose of the Study:

    • To highlight the growing problem of incorrect stereochemical representations.
    • To emphasize the need for rigorous verification of chemical structures, especially beta-D-glucuronides.

    Main Methods:

    • Review of scientific literature for stereochemistry accuracy.
    • Identification of common errors in beta-D-glucuronide representation.

    Main Results:

    • Confirmed prevalence of incorrect stereochemistry in published scientific works.
    • Documented numerous instances of inaccurate beta-D-glucuronide structures.

    Conclusions:

    • Assuming correctness of "lifted" or "copied" stereochemical formulas is unsafe.
    • Adherence to fundamental rules and conventions for stereochemical representation is essential to avoid future errors.

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