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Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population

Dan Rong1, Jie Liu2, Xin Jia1

  • 1Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China.

Atherosclerosis
|June 27, 2017
PubMed

Insights

High homocysteine levels (HHcy) are an independent risk factor for peripheral arterial disease (PAD) in the Chinese population. Further research is needed to confirm this association and explore homocysteine-lowering therapies.

Area of Science:

  • Cardiovascular Science
  • Vascular Medicine
  • Biochemistry

Background:

  • Hyperhomocysteinemia (HHcy) is a suspected risk factor for atherosclerosis.
  • The link between HHcy and peripheral arterial disease (PAD) remains debated.
  • Limited research exists on HHcy and PAD within the Chinese population.

Purpose of the Study:

  • To investigate the association between HHcy and PAD risk in a Chinese cohort.
  • To determine if HHcy is an independent risk factor for PAD.

Main Methods:

  • Cross-sectional study involving 240 PAD patients and 240 controls.
  • Serum total homocysteine levels and ankle-brachial indexes (ABIs) were measured.
  • Multivariable logistic regression, interaction, and stratified analyses were performed.

Main Results:

  • Elevated serum homocysteine levels were significantly associated with an increased risk of PAD.
  • HHcy demonstrated an independent association with PAD, irrespective of traditional vascular risk factors.
  • No interactive effect was observed between HHcy and other risk factors for PAD.

Conclusions:

  • Hyperhomocysteinemia is confirmed as an independent risk factor for peripheral arterial disease in the Chinese Han population.
  • Further prospective, randomized clinical trials are warranted to establish causality and evaluate homocysteine-lowering interventions.
Abstract

Keywords:
Case-control studyHomocysteineHyperhomocysteineamiaPeripheral arterial disease

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