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Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer
Hidehisa Mori1, Tomoharu Fukumori2, Kei Daizumoto2
1Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan hidehisa-mori0711@sirius.ocn.ne.
Background:
We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder.
Materials And Methods:
Four hundred and four patients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution.
Results:
In cases with prostate volume more than 30 cm3, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution.
Conclusion:
Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder.
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