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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilic myocarditis and hypereosinophilic syndrome

Hanane Boussir1, Amine Ghalem1, Nabila Ismaili1

  • 1Department of Cardiology, University Hospital of Mohammed VI, Oujda, MoroccoMorocco.

Journal of the Saudi Heart Association
|June 28, 2017
PubMed

Insights

Hypereosinophilic syndrome (HES) can cause severe cardiac damage. This case highlights a favorable outcome in a patient with eosinophilic myocarditis and cardiogenic shock through prompt, multi-faceted treatment.

Area of Science:

  • Hematology
  • Cardiology
  • Immunology

Background:

  • Hypereosinophilic syndrome (HES) is a rare hematological disorder.
  • Cardiac involvement in HES, though uncommon, significantly worsens prognosis.
  • Cardiac injury in HES progresses through infiltration, thrombosis, and fibrosis stages.

Purpose of the Study:

  • To report a case of hypereosinophilic syndrome with significant cardiac involvement.
  • To illustrate the management and outcome of eosinophilic myocarditis in cardiogenic shock.
  • To discuss the challenges and therapeutic approaches for cardiac HES.

Main Methods:

  • Case report of a 33-year-old female patient.
  • Diagnosis of HES with pulmonary, gastrointestinal, and cardiac involvement.
  • Treatment included dobutamine, anticoagulation, corticosteroids, beta-blockers, and ACE inhibitors.

Main Results:

  • The patient presented with eosinophilic myocarditis and cardiogenic shock.
  • A favorable clinical evolution was observed with the implemented treatment regimen.
  • This case demonstrates successful management of severe cardiac HES.

Conclusions:

  • Cardiac involvement in HES is a critical complication requiring aggressive management.
  • Corticosteroids remain a primary treatment, but combination therapies are essential.
  • Prompt diagnosis and multidisciplinary treatment can improve outcomes in HES-related cardiac injury.

Keywords:
Cardiogenic shockCorticosteroidsEosinophilic myocarditisHypereosinophilic syndromeImatinib

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