Related Experiment Video

Updated: Feb 27, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.3K

Current perspective on emergence, diagnosis and drug resistance in Candida auris

Smita Sarma1, Shalini Upadhyay1

  • 1Department of Microbiology, Medanta - The Medicity, Gurgaon, Haryana, India.

Infection and Drug Resistance
|June 28, 2017
PubMed

Insights

Candida auris (C. auris) is a growing global health threat due to its resistance to antifungal drugs and diagnostic difficulties. This review covers its emergence, resistance patterns, and management strategies.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Emerging fungal pathogen Candida auris (C. auris) poses a significant global health risk.
  • C. auris presents diagnostic challenges with conventional methods.
  • The fungus exhibits reduced susceptibility and resistance to major antifungal drug classes.

Purpose of the Study:

  • To review the global emergence trends of Candida auris.
  • To discuss the associated risk factors and antifungal resistance patterns.
  • To address diagnostic challenges and explore prevention and therapeutic strategies for C. auris infections.

Main Methods:

  • Literature review of global emergence and resistance data for Candida auris.
  • Analysis of diagnostic challenges and limitations of current methods.
  • Evaluation of existing and potential therapeutic options and prevention strategies.

Main Results:

  • Candida auris is emerging globally with increasing frequency.
  • Drug resistance, particularly multidrug resistance, is a significant concern.
  • Accurate and rapid diagnostics remain a challenge for C. auris detection.

Conclusions:

  • Candida auris represents a critical threat requiring enhanced surveillance and infection control.
  • Multidrug resistance necessitates the development of novel antifungal agents and treatment approaches.
  • Improved diagnostic tools and global collaboration are essential for managing C. auris outbreaks.
Keywords:
Candida haemuloniiCandidemiadrug resistanceoutbreak

More Related Videos

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research09:06

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

1.1K
Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis09:44

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

3.3K

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
54