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Updated: Feb 27, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Precision medicine approach to genetic cardiomyopathy
K Filonenko1, H A Katus1,2, B Meder3,4
1Institute for Cardiomyopathies Heidelberg, University Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany.
Abstract:
Precision medicine aims to achieve improved survival by strategies that recognize the genetic and phenotypic individuality of patients and stratify treatment accordingly. Genetic cardiomyopathies represent an ideal disease group to fully embark on this concept: they are in total frequent diseases with a marked morbidity and mortality and there is ample knowledge about their predisposing genetic factors and associated functional mechanisms. The current review highlights the genetic etiology and gives examples of the diverse treatment strategies that are envisaged in the future.
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