Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antibodies Cross-Reactive with Bundibugyo Virus in Ferrets Vaccinated with Ebola Virus Vaccine.

Emerging infectious diseases·2026

Same author

Development of an immunochromatographic lateral flow assay for the rapid detection of all known orthoebolavirus glycoproteins.

Npj viruses·2026

Same author

Local immune responses in tick-bite skin during SFTSV infection are associated with type I interferon signaling and monocyte-lineage cell recruitment.

Molecular immunology·2026

Same author

Characterization of atypical Ebola virus disease in ferrets.

PLoS pathogens·2026

Same author

Multilevel Residual Complexity Analysis Reveals Origin of Nanomolar Antiviral Bioactives of "Isoquercitrin".

Journal of natural products·2026

Same author

Characterization of Atypical Ebola Virus Disease in Ferrets.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Small Animal Models for Studying Filovirus Pathogenesis.

Satoko Yamaoka¹, Logan Banadyga², Mike Bray³

¹Department of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Current Topics in Microbiology and Immunology

|June 28, 2017

Summary

This summary is machine-generated.

Filovirus research utilizes adapted viruses in rodent models like mice and hamsters to study disease mechanisms. These models, including new mouse strains, offer insights into filovirus pathogenesis and virulence factors.

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

Related Experiment Videos

Last Updated: Feb 27, 2026

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

Area of Science:

Virology
Pathogenesis
Animal Models

Background:

Small animal models are crucial for filovirus research.
Wild-type filoviruses cause limited disease in immunocompetent rodents.
Adapted filoviruses are developed via sequential passage for disease modeling.

Purpose of the Study:

To comprehensively review filovirus rodent models and adapted viruses.
To detail clinical and pathological features in various rodent models.
To explore molecular determinants of filovirus adaptation and virulence.

Main Methods:

Summarizing existing literature on filovirus rodent models.
Describing clinical and pathological findings in infected rodents.
Analyzing molecular mechanisms of virus adaptation and virulence.

Main Results:

Rodent models, including adapted viruses and immunodeficient strains, are vital for studying filovirus pathogenesis.
Comparative analyses reveal insights into pathogenicity and species-specific virulence.
New models like humanized and CC-RIX mice expand research capabilities.

Conclusions:

Rodent models are indispensable for understanding filovirus infection.
Adapted viruses and specific mouse models enhance research on pathogenesis and host response.
Evaluating model advantages and disadvantages guides future filovirus studies.