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[Cleft lip and palate].

A Voigt1,2, R J Radlanski3, N Sarioglu4

  • 1Arbeitsbereich Lippen‑, Kiefer‑, Gaumen-Spalten, Klinik für Mund‑, Kiefer‑, Gesichts-Chirurgie, Charité - Campus Virchow, Augustenburger Platz 1, 13353, Berlin, Deutschland. alexander.voigt@charite.de.

Der Pathologe
|June 28, 2017
PubMed
Summary

Cleft lip and palate (CLP) subtypes have diverse causes and outcomes. Understanding these differences is crucial for accurate diagnosis, treatment, and prognosis in affected individuals.

Keywords:
Non-syndromic cleft lip and palatePaidopathological aspectsRobin sequenceSucking disorderSyndromic

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Area of Science:

  • Craniofacial development and malformation research.

Background:

  • Cleft lip and palate (CLP) are malformations with unknown etiology but similar phenotypes.
  • This similarity impacts diagnostics, therapy, prevention, prognosis, and risk assessment.

Purpose of the Study:

  • Define CLP subtypes and their embryonic origins.
  • Clarify correlations and differences using epidemiological data.
  • Review genetic analyses, syndrome associations, and clinical implications.

Main Methods:

  • Review of facial embryological development.
  • Synthesis of epidemiological and genetic studies.
  • Consideration of pedopathological and forensic aspects.

Main Results:

  • Syndromic and non-syndromic CLP present distinct etiologies, treatments, and prognoses.
  • Differentiating between subgroups requires thorough understanding.
  • Article provides an overview for understanding these malformations.

Conclusions:

  • Distinguishing CLP subtypes is essential for effective clinical management.
  • Comprehensive knowledge aids in understanding the complexities of CLP.
  • This review supports improved diagnostic and therapeutic strategies for CLP.