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Syphilis testing practices in the Americas.

Thuy T Trinh1, Mary L Kamb1, Minh Luu2

  • 1Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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|June 28, 2017
PubMed
Summary
This summary is machine-generated.

Syphilis testing in the Americas faces challenges. Laboratories report issues with supplies, training, and equipment, impacting quality assurance and appropriate testing practices.

Keywords:
AmericasAméricasAmériquesOrganisation Panaméricaine de la Santé (OPS)Organización Panamericana de la Salud (OPS)Pan American Health OrganizationSífilis congénitaassurance qualité de laboratoirecongenital Syphilisdépistage de la syphiliseliminación de la transmisión vertical de la sífilis y el VIHelimination of mother-to-child transmission of syphilis and HIVgarantía de calidad de laboratoriolaboratory quality assuranceprueba de sífilissyphilis congénitalesyphilis testingélimination de la transmission mère-enfant de la syphilis et du VIH

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Area of Science:

  • Public Health
  • Infectious Disease Epidemiology
  • Laboratory Science

Background:

  • Syphilis remains a significant public health concern globally.
  • Accurate and accessible syphilis testing is crucial for disease control and prevention.
  • Understanding current laboratory practices is essential for improving diagnostic capabilities.

Purpose of the Study:

  • To assess the current landscape of syphilis testing policies and practices across laboratories in the Americas.
  • To identify common diagnostic methods, testing algorithms, and quality assurance strategies employed.
  • To pinpoint challenges faced by laboratories in implementing effective syphilis testing.

Main Methods:

  • A 2014 survey by the Pan American Health Organization collected data from laboratories in 35 member states.
  • A semi-structured questionnaire gathered information on syphilis tests, algorithms, equipment, quality assurance, and challenges.
  • Data were collected from 69 laboratories, including national/regional reference and lower-level facilities.

Main Results:

  • Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) tests were most common.
  • Only a small percentage of laboratories utilized direct detection or rapid syphilis tests.
  • While most laboratories employed some quality assurance strategies, few implemented all basic measures.
  • Common challenges included reagent stock-outs, insufficient staff training, and inadequate equipment.

Conclusions:

  • Many laboratories in the Americas encounter difficulties in performing appropriate syphilis testing.
  • Ensuring the quality of syphilis testing remains a significant challenge for reference and clinical laboratories in the region.
  • Addressing these challenges is critical for effective syphilis control programs.