Circumcision does not have effect on premature ejaculation: A systematic review and meta-analysis.

Area of Science:

• Urology
• Sexual Health
• Men's Health

Background:

• Premature ejaculation (PE) is a common male sexual dysfunction.
• The potential impact of circumcision on male sexual function, including PE, remains a subject of interest and debate.

Purpose of the Study:

• To systematically evaluate the effect of circumcision on premature ejaculation (PE) through a meta-analysis.
• To assess related sexual function parameters such as intravaginal ejaculation latency time (IELT), orgasm difficulty, erectile dysfunction (ED), and intercourse pain.

Main Methods:

• A comprehensive literature search was conducted across PubMed, EMBASE, and Google Scholar databases up to May 1, 2016.
• Twelve studies involving 10019 circumcised and 11570 uncircumcised men were included in the meta-analysis.
• Data analysis utilized Cochrane Collaboration's RevMan 5.2 software with fixed or random-effect models based on heterogeneity.

Main Results:

• The meta-analysis revealed no statistically significant difference in the prevalence of premature ejaculation (PE) between circumcised and uncircumcised men (OR, 0.90; p=0.37).
• Similarly, no significant difference was observed in the difficulty of achieving orgasm (OR, 1.04; p=0.65).
• However, the circumcised group showed favorable outcomes in terms of longer intravaginal ejaculation latency time (IELT) (OR, 0.72; p<0.00001), reduced erectile dysfunction (ED) (OR, 0.42; p=0.40), and less pain during intercourse (OR, 0.36; p=0.007).

Conclusions:

• Circumcision does not appear to have a significant effect on premature ejaculation (PE).
• The findings suggest potential benefits of circumcision regarding intravaginal ejaculation latency time (IELT), erectile dysfunction (ED), and intercourse-related pain.
• Further research may explore the mechanisms behind these observed differences in sexual function parameters.