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Periprostatic adipose inflammation is associated with high-grade prostate cancer
A Gucalp1,2, N M Iyengar1,2, X K Zhou3
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Prostate Cancer and Prostatic Diseases
|June 28, 2017
Summary
Inflammation in fat tissue surrounding the prostate is common in men with prostate cancer (PC). This periprostatic white adipose tissue (WAT) inflammation is linked to higher-grade PC and obesity.
Area of Science:
- Oncology
- Metabolic Syndrome
- Inflammation Biology
Background:
- Obesity is linked to subclinical inflammation and increased risk of high-grade prostate cancer (PC).
- The role of inflammation in periprostatic white adipose tissue (WAT) and its contribution to obesity's impact on PC aggressiveness remains unclear.
Purpose of the Study:
- To determine the prevalence of inflammation in periprostatic WAT in men with PC.
- To explore associations between periprostatic WAT inflammation and clinical/systemic factors, including PC grade and obesity indicators.
Main Methods:
- Cross-sectional study of 169 men undergoing radical prostatectomy for newly diagnosed PC.
- Periprostatic WAT inflammation assessed via CD68 immunohistochemistry for crown-like structures (CLS-P).
- Analysis of tumor characteristics, BMI, adipocyte size, and metabolic markers; statistical tests included Wilcoxon rank-sum, Chi-square, Fisher's exact, and generalized linear regression.
Main Results:
- Periprostatic WAT inflammation detected in 49.7% of patients.
- Inflammation associated with higher BMI, larger adipocyte size, and Gleason grade groups IV/V PC.
- Adjusted analysis confirmed WAT inflammation's link to high-grade PC.
- Correlations observed with elevated insulin, triglycerides, leptin/adiponectin ratio, and decreased HDL cholesterol.
Conclusions:
- Periprostatic WAT inflammation is prevalent in men with prostate cancer.
- This inflammation is significantly associated with high-grade prostate cancer, independent of BMI.
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