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Updated: Feb 27, 2026

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury
Published on: August 3, 2015
Evaluation of nephroprotective activity of Musa paradisiaca L. in gentamicin-induced nephrotoxicity
Khizar Abbas1, Ghazala H Rizwani2, Hina Zahid2
1Department of Pharmacognosy, and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan / Department of Pharmacognosy, Faculty of pharmaceutical Sciences, GC University Faisalabad, Faisalabad, Pakistan.
Abstract:
The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts (bract, flower, trachea and tracheal fluid) of Musa paradisiaca L. (Family: Musaceae) against gentamicin-induced nephrotoxicity in mice. Gentamicin produced significant changes in biochemical (increased levels of blood urea nitrogen level, blood urea, and serum creatinine), and histological parameters in mice. Treatment with methanolic extract of bract (100 and 250mg/kg, b.w) and flowering stalk (trachea) (250 and 500mg/kg, b.w) significantly prevented biochemical and histological changes produced by gentamicin toxicity. The extracts of M. paradisiaca (bract and flowering stalk) could contribute a lead to discovery of a new drug for the treatment of drug-induced nephrotoxicity.
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