Related Experiment Video
Updated: Aug 10, 2026
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
Published on: August 19, 2020
Report - Cerebral electrical impedance value reflects brain edema caused by cardiopulmonary bypass in infants
Mingqing Peng1, Chunbao Guo2, Fang Gong3
1Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
Insights
Cerebral electrical impedance (CEI) can monitor brain edema in infants during cardiopulmonary bypass (CPB). Dynamic CEI changes reflect brain damage, with higher detection rates in longer CPB procedures.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pediatric Cardiology
Background:
- Infants undergoing cardiopulmonary bypass (CPB) are at risk for brain injury and edema.
- Monitoring brain edema dynamically during CPB is crucial for patient outcomes.
- Existing methods for monitoring brain edema may have limitations in infants.
Purpose of the Study:
- To investigate the utility of dynamic cerebral electrical impedance (CEI) changes for monitoring brain edema in infants during CPB.
- To correlate CEI changes with established biomarkers of brain injury.
Main Methods:
- Prospective study of 40 infants undergoing CPB for congenital heart disease, divided into groups based on aortic cross-clamping (ACC) time.
- Comparison with 20 infants undergoing inguinal hernia repair (controls).
- Measurement of CEI using the BORN-BE system, and serum levels of S100 protein and neuron-specific enolase (NSE) before and after CPB.
Main Results:
- CPB groups showed significant increases in CEI, S100, and NSE levels compared to controls during surgery, with subsequent decreases post-surgery.
- Higher detection rates of cerebral edema were observed 24 hours post-operatively in the group with longer ACC times (CPB-B).
- CEI values demonstrated dynamic changes correlating with brain injury markers.
Conclusions:
- Dynamic CEI monitoring is a viable method for assessing brain edema in infants during CPB.
- CEI serves as a sensitive index reflecting brain damage in infants undergoing CPB.
- ACC time is a significant factor influencing the development of cerebral edema during CPB.
Abstract:
The study aimed to investigate if the dynamic changes in cerebral electrical impedance (CEI) values could be used to monitor brain edema during cardiopulmonary bypass (CPB) in infants. Forty infants (mean age: 1.4±0.38y) with acyanotic congenital heart disease who underwent CPB open-heart surgery between September 2009 and March 2010 were prospectively enrolled, and divided into 2 groups based on aortic cross-clamping (ACC) time: CPB-A (ACC<50 min) and CPB-B (ACC<50 min). During the same period, twenty infants (aged 1-3y) who underwent surgery for indirect inguinal hernias were selected as controls. Serum astrocyte S100 protein (S100) and neuron-specific enolase (NSE) levels were determined before and after CPB. Changes in CEI were detected using the BORN-BE system. No intraoperative death occurred. Compared with controls, left and right side CEI values, serum S100 and NSE levels in the CPB groups significantly increased from surgery beginning to end (P<0.05). After surgery, these levels decreased (P<0.05). Detection rates of cerebral edema in the CPB-B group 24h post-operative were significantly higher than in the CPB-A group (P<0.05). CEI value can be used to dynamically monitor brain edema in infants undergoing CPB, and is an index reflecting brain damage during CPB in infants.
Related Concept Videos
01:19Cerebral Edema l: Introduction
01:22Cerebral Edema ll: Pathophysiology