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Related Experiment Videos

Iris involvement in granulocytic sarcoma.

H D Perry, F J Mallen

    American Journal of Ophthalmology
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Granulocytic sarcoma, a manifestation of leukemia, can present as iris nodules. This case highlights ocular involvement in a child with acute myeloid leukemia in remission, emphasizing the importance of recognizing these eye findings.

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    Area of Science:

    • Ophthalmology
    • Hematology
    • Oncology

    Background:

    • Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow.
    • Ocular involvement in leukemia can occur, even during remission.
    • Granulocytic sarcoma, also known as myeloid sarcoma, is a tumor composed of immature myeloid cells.

    Observation:

    • A 6-year-old boy with AML in remission developed unilateral, then bilateral, ocular inflammation.
    • Symptoms included uveitis, hypopyon, and vitreous hemorrhage.
    • Ocular pathology revealed leukemic infiltrates throughout various eye structures.

    Findings:

    • Leder stain confirmed granulocytic sarcoma.
    • The infiltrates were identified in the conjunctiva, episclera, sclera, ciliary body, trabecular meshwork, Schlemm's canal, choroid, vitreous, and iris.

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  • Iris nodules were a prominent feature of the leukemic infiltration.

    • Implications:

    • Granulocytic sarcoma can manifest intraocularly as iris nodules.
    • Ocular findings, such as iris nodules, may be the initial sign of granulocytic leukemia.
    • Early recognition of ocular leukemia is crucial for timely diagnosis and management.