Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between...

Perceptual segregation of multiple sounds, which overlap in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFR_TFS) and the slow-varying envelope component (FFR_ENV). When a single narrowband noise was presented alone, the FFR_TFS, but not the FFR_ENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFR_TFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFR_ENV. These results suggest that the FFR_TFS and FFR_ENV represent two distinct types of signal processing in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFR_TFS is more critical to spatial release from masking.