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Related Experiment Videos

An outbreak of shingles?

S R Palmer, E O Caul, D E Donald

    Lancet (London, England)
    |November 16, 1985
    PubMed
    Summary
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    An office outbreak showed a higher incidence of shingles than expected. This suggests that reexposure to the varicella-zoster virus may trigger shingles, especially after a preceding illness.

    Area of Science:

    • Epidemiology
    • Infectious Diseases
    • Virology

    Background:

    • Shingles (herpes zoster) is caused by the reactivation of the varicella-zoster virus (VZV).
    • While typically sporadic, understanding outbreak dynamics and triggers is crucial for public health.
    • Previous illness is a known risk factor for VZV reactivation.

    Purpose of the Study:

    • To investigate an unusual cluster of shingles cases within a specific department of an office complex.
    • To determine potential risk factors and triggers for shingles during this outbreak.
    • To explore the role of VZV reexposure in shingles development.

    Main Methods:

    • Descriptive epidemiology of shingles cases within the office complex.
    • Serological testing for Varicella-zoster virus-specific IgM antibodies in cases and controls.

    Related Experiment Videos

  • Case-control study to identify risk factors, including recent preceding illness.

    • Main Results:

    • Shingles incidence was significantly higher in the index department compared to the general workforce.
    • VZV-specific IgM antibodies were detected in outbreak cases but not in controls.
    • Clustering of cases in time and by work area was observed.
    • Recent preceding illness was identified as a risk factor for shingles in outbreak cases.

    Conclusions:

    • The observed shingles outbreak suggests that reexposure to the varicella-zoster virus can provoke shingles.
    • Preceding illness may increase susceptibility to VZV reactivation and shingles development.
    • Workplace environments warrant consideration for potential VZV transmission dynamics during outbreaks.