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Intestinal lymphatic vasculature: structure, mechanisms and functions
Jeremiah Bernier-Latmani1, Tatiana V Petrova1,2
1Department of Fundamental Oncology, Ludwig Institute for Cancer Research and Institute of Pathology, Centre Hospitalier Universitaire Vaudois and University of Lausanne (UNIL), Chemin des Boveresses 155, Epalinges, Switzerland.
Nature Reviews. Gastroenterology & Hepatology
|June 29, 2017
Summary
This review details the structure, development, and function of mammalian intestinal lymphatics. It explores their role in fluid balance, nutrient transport, and disease, highlighting lymphatic patterning and regulation.
Area of Science:
- Gastroenterology and Immunology
- Vascular Biology
- Lymphatic System Research
Background:
- Mammalian intestinal lymphatic vasculature is crucial for fluid homeostasis, immune surveillance, and nutrient absorption.
- These vessels transport interstitial fluid, antigens, immune cells, dietary lipids, and fat-soluble vitamins.
Purpose of the Study:
- To provide a comprehensive overview of intestinal lymphatic organization, structure, and development.
- To elucidate molecular mechanisms governing lymphatic patterning and maintenance.
- To discuss lymph flow regulation and the role of intestinal lymphatics in diseases like IBD, infection, and cancer.
Main Methods:
- This is a review article, synthesizing existing research and knowledge.
- Information is compiled from studies on lymphatic development, molecular biology, physiology, and pathology.
Main Results:
- Detailed insights into the anatomical and structural organization of intestinal lymphatics.
- Current understanding of the developmental origins and molecular pathways regulating lymphatic patterning.
- Discussion of physiological regulation of intestinal lymph flow and emerging disease associations.
Conclusions:
- Intestinal lymphatics are complex and vital for gut health and systemic functions.
- Further research into lymphatic mechanisms can reveal new therapeutic targets for various diseases.
- This review consolidates current knowledge, providing a foundation for future investigations.
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