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Equilibrium and Balance

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...

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Related Experiment Video

Updated: Feb 27, 2026

Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT

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Preventing Episodic Migraine With Caloric Vestibular Stimulation: A Randomized Controlled Trial.

David Wilkinson¹, Kristen K Ade², Lesco L Rogers²

¹School of Psychology, University of Kent, Canterbury, Kent, UK.

|June 29, 2017

Summary

A novel caloric vestibular stimulation (CVS) device effectively reduced monthly migraine days in adults. This safe and tolerable treatment offers a new option for episodic migraine prevention.

Keywords:

brainstem caloric vestibular stimulation episodic migraine noninvasive neuromodulation prophylactic

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Area of Science:

Neurology
Medical Devices
Clinical Trials

Background:

Migraine affects 12% of the global population, causing significant disability.
Current preventive treatments have limitations, including inadequate efficacy and adverse events, necessitating novel therapeutic options.
Caloric vestibular stimulation (CVS) presents a potential adjunctive therapy for migraine prevention.

Purpose of the Study:

To assess the safety and efficacy of a new solid-state caloric vestibular stimulation (CVS) device.
To evaluate the device as an adjuvant therapy for preventing episodic migraine in adults.

Main Methods:

A multicenter, randomized, placebo-controlled trial involving adult migraineurs.
Three months of treatment with the TNM™ device for CVS.
Primary endpoint: change in monthly migraine days; secondary endpoints: responder rates, analgesic use, pain scores, and safety assessments.

Main Results:

Active treatment group showed a significant reduction in monthly migraine days (-3.9 days) compared to placebo (-1.1 days).
Greater improvements observed in acute medication usage and pain scores in the active group.
The device was well-tolerated, with no adverse effects on mood, cognition, or balance, and high treatment adherence (90%).

Conclusions:

The TNM™ device for CVS demonstrates clinical efficacy and high tolerability.
It represents a promising adjuvant therapy for the prevention of episodic migraine.
The study supports CVS as a safe and effective non-pharmacological migraine management strategy.