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ECG markers associated with ischemic stroke at young age - a case-control study

Jani Pirinen1,2,3, Antti Eranti4, Paul Knekt5

  • 1a Department of Cardiology , Heart and Lung Center, Helsinki University Hospital, University of Helsinki , Helsinki , Finland.

Annals of Medicine
|June 29, 2017
PubMed

Insights

Electrocardiogram (ECG) markers indicating atrial pathology, such as P-wave abnormalities and left ventricular hypertrophy (LVH), are linked to increased ischemic stroke risk in young adults. These ECG findings were particularly associated with cardioembolic and cryptogenic stroke subtypes.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Diagnostics

Background:

  • Electrocardiogram (ECG) abnormalities are recognized risk factors for ischemic stroke (IS), particularly the cardioembolic subtype.
  • Markers of left ventricular hypertrophy (LVH) and atrial pathology on ECG, beyond atrial fibrillation, are associated with elevated IS risk.

Purpose of the Study:

  • To investigate the association between specific ECG markers of atrial abnormality and IS in young adults.
  • To identify ECG patterns indicative of increased IS risk in the 15-49 age group.

Main Methods:

  • A case-control study involving 567 IS patients and 1033 controls aged 15-49 years.
  • ECGs were analyzed for P-terminal force (PTF), interatrial blocks (IAB), and LVH.
  • Conditional logistic regression was employed to assess associations.

Main Results:

  • Interatrial blocks (IAB) and P-terminal force (PTF) combined with LVH showed independent association with IS.
  • LVH, abnormal P-wave, PTF, and IAB, along with their combinations with LVH, were linked to the cardioembolic stroke subtype.
  • Abnormal P-wave and IAB were associated with cryptogenic stroke.

Conclusions:

  • ECG patterns reflecting atrial pathology serve as significant markers for increased ischemic stroke risk in young adults.
  • These ECG markers are associated with both cardioembolic and cryptogenic subtypes of IS, highlighting their diagnostic utility.
Abstract

Keywords:
CardioembolismP-wavecase-control studycryptogenic strokeelectrocardiographicembolic strokes of undetermined sourceleft ventricular hypertrophystrokestroke in the young

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