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Published on: October 15, 2010
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Endothelial dysfunction in children with type 1 diabetes mellitus.
Antonella Márcia Mercadante de Albuquerque do Nascimento1,2,3, Inês Jorge Sequeira4, Daniel França Vasconcelos2
1Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, Brasília, DF, Brasil.
Archives of Endocrinology and Metabolism
|June 29, 2017
Summary
Children with Type 1 diabetes mellitus (T1DM) show impaired endothelial function, particularly with longer disease duration. This dysfunction, linked to hyperglycemia, may precede structural atherosclerotic changes.
Area of Science:
- Pediatric endocrinology
- Cardiovascular research
- Diabetes mellitus complications
Background:
- Type 1 diabetes mellitus (T1DM) is a chronic condition requiring lifelong management.
- Early detection of cardiovascular risk factors in children with T1DM is crucial.
- Endothelial dysfunction is an early marker of atherosclerosis.
Purpose of the Study:
- To investigate endothelial dysfunction in children with T1DM.
- To assess early structural atherosclerotic changes in pediatric T1DM.
- To correlate these findings with disease duration and glycemic control.
Main Methods:
- Study included 31 children with T1DM (aged 6-12) and 58 healthy controls.
- T1DM group divided by disease duration (<5 years vs. >5 years).
- Flow-mediated dilation (FMD) of brachial artery and carotid intima-media thickness (IMT) measured via ultrasonography.
Main Results:
- Significantly reduced FMD in T1DM children with longer disease duration compared to controls.
- No significant differences in IMT between T1DM and control groups.
- FMD showed a negative correlation with HbA1c and fasting glucose levels.
Conclusions:
- Endothelial dysfunction is present in children with T1DM, especially after 5 years of diagnosis.
- This dysfunction may occur before structural atherosclerotic changes are evident.
- Hyperglycemia is associated with impaired vasodilation in pediatric T1DM.
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