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Updated: Feb 27, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis of the Right-Side Structure of Type B Physalins
Masaki Morita1,2, Shuntaro Kojima1, Megumi Ohkubo1
1Synthetic Organic Chemistry Laboratory RIKEN2-1 Hirosawa Wako Saitama 351-0198 Japan.
Abstract:
We present a full account of our synthetic studies on the racemic DEFGH-ring moiety of physalins, featuring domino ring transformation of a tricyclic key intermediate. We also report the results of a detailed mechanistic examination of the domino ring transformation, as well as a reoptimization of the 2,3-Wittig rearrangement and methylation steps. Furthermore, we have newly established a method for the preparation of an optically active synthetic intermediate by enzymatic kinetic resolution. Our work provides access to both natural and nonnatural right-side physalin structures.
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