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Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular
Stephanie D Hoekstra1, Sven Stringer1, Vivi M Heine1,2
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit AmsterdamAmsterdam, Netherlands.
Abstract:
Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.
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