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Relationship between RAGE gene polymorphisms and cardiovascular disease prognosis in the Chinese Han population

Jinxiong Gao1,2, Liehua Deng1, Ying Wang2

  • 1Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 Northern Guangzhou Ave, Guangzhou, 510515, Guangdong, China.

Molecular Genetics and Genomics : MGG
|June 30, 2017
PubMed

Insights

The G82S variant in the RAGE gene increases the risk of death and acute myocardial infarction (AMI) in the Chinese Han population. Other RAGE gene polymorphisms studied did not impact cardiovascular disease prognosis.

Area of Science:

  • Genetics
  • Cardiology
  • Population Health

Background:

  • Cardiovascular disease (CVD) is a major cause of mortality in China.
  • The Receptor for Advanced Glycation End products (RAGE) gene is implicated in various diseases.
  • Understanding genetic risk factors for CVD prognosis in specific populations is crucial.

Purpose of the Study:

  • To investigate the association between RAGE gene polymorphisms and cardiovascular disease prognosis in the Chinese Han population.
  • To evaluate the prognostic impact of three RAGE gene polymorphisms: -429T/C, 1704G/T, and G82S.
  • To determine if RAGE gene variants influence the risk of cardiovascular events and mortality.

Main Methods:

  • A cohort study involving 425 subjects from Guangdong province, China.
  • Genotyping of RAGE gene polymorphisms (-429T/C, 1704G/T, G82S) using Polymerase Chain Reaction/Restriction Fragment Length Polymorphism (PCR-RFLP).
  • Long-term follow-up (6.5 years) for cardiovascular events and all-cause mortality, analyzed with logistic regression and Kaplan-Meier methods.

Main Results:

  • The G82S polymorphism in the RAGE gene was significantly associated with a higher risk of all-cause mortality and acute myocardial infarction (AMI).
  • Subjects with the G82S 'S' mutation showed a markedly increased risk compared to wild-type homozygotes.
  • The -429T/C and 1704G/T polymorphisms of the RAGE gene showed no significant association with cardiovascular disease prognosis.

Conclusions:

  • The G82S variant of the RAGE gene is a significant predictor of increased all-cause mortality and AMI risk in the Chinese Han population.
  • RAGE gene G82S polymorphism may play a role in the pathogenesis or progression of cardiovascular diseases.
  • Targeting or monitoring individuals with the G82S RAGE gene variant could be beneficial for CVD risk management.

Keywords:
Coronary artery diseaseHypertensionPolymorphismPrognosisRAGE

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