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Plasma peptide YY (PYY) in dumping syndrome.
Digestive Diseases and Sciences
|December 1, 1985
Summary
Oral glucose significantly increases peptide YY (PYY) release in dumping syndrome patients. Somatostatin blocks this PYY release, suggesting it modulates PYY
Area of Science:
- Gastroenterology
- Endocrinology
- Human Physiology
Background:
- Peptide YY (PYY) is a hormonal peptide primarily found in the lower intestinal mucosa.
- Dumping syndrome is a condition affecting digestion after stomach surgery.
Purpose of the Study:
- To investigate the effect of oral glucose on PYY release in patients with dumping syndrome.
- To determine the role of somatostatin in modulating PYY release.
Main Methods:
- Studied plasma PYY concentrations in six dumping syndrome patients after oral glucose administration.
- Investigated the effect of somatostatin infusion on PYY release in response to glucose.
Main Results:
- Oral glucose caused significantly higher plasma PYY concentrations in dumping syndrome patients compared to healthy controls.
- Somatostatin infusion completely inhibited glucose-induced PYY release.
- PYY was found to inhibit gastric acid secretion and emptying at relevant concentrations.
Conclusions:
- Dumping syndrome is associated with exaggerated PYY release following oral glucose.
- Local somatostatin in the gut may regulate PYY release.
- PYY may play a role in the pathophysiology of dumping syndrome.