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Therapeutic potentials of adenosine receptors agonists and antagonists in colitis; Current status and perspectives

Amirhossein Bahreyni1, Seyed S Samani2, Majid Khazaei3

  • 1Faculty of Medicine, Department of Clinical Biochemistry and Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

Journal of Cellular Physiology
|June 30, 2017
PubMed

Insights

Adenosine dysregulation impacts ulcerative colitis (UC) development and progression. Targeting adenosine receptors with agonists or antagonists may offer new therapeutic strategies for managing colitis.

Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Ulcerative colitis (UC) involves adenosine dysregulation, influencing disease pathogenesis.
  • Adenosine's role in inflammatory responses like epithelial barrier function and motility is implicated in colitis.

Purpose of the Study:

  • To review the role of adenosine receptors (ARs) in ulcerative colitis (UC) pathogenesis.
  • To explore the therapeutic potential of AR agonists and antagonists in managing colitis.

Main Methods:

  • Literature review of studies investigating adenosine and its receptors in colitis models and patients.
  • Analysis of evidence linking adenosine metabolism and AR signaling to UC pathology.

Main Results:

  • Adenosine generating enzyme activity is altered in colitis patients.
  • Adenosine modulates key inflammatory pathways relevant to UC.
  • AR agonists and antagonists demonstrate therapeutic effects in preclinical colitis models.

Conclusions:

  • Adenosine signaling is a critical factor in UC pathogenesis.
  • Modulating adenosine receptors presents a promising therapeutic avenue for ulcerative colitis treatment.
Keywords:
adenosineadenosine receptorscolitisinflammatory bowel diseasesreceptor agonist/antagonist

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