Engineered Heart Repair
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Updated: Feb 27, 2026
Implantation of Engineered Tissue in the Rat Heart
Published on: June 24, 2009
B Fujita1,2,3, W-H Zimmermann1,2
1Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.
Abstract:
There is a pressing need for the development of advanced heart failure therapeutics. Current state-of-the-art is protection from neurohumoral overstimulation, which fails to address the underlying cause of heart failure, namely loss of cardiomyocytes. Implantation of stem cell-derived cardiomyocytes via tissue-engineered myocardium is being advanced to realize the remuscularization of the failing heart. Here, we discuss pharmacological challenges pertaining to the clinical translation of tissue-engineered heart repair with a focus on engineered heart muscle (EHM).
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