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Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and

Vladimir Kostyuk1, Alla Potapovich1, Ahmed R Albuhaydar1

  • 11 Department of Biology, Byelorussian State University , Minsk, Belarus .

Rejuvenation Research
|June 30, 2017
PubMed

Insights

Natural compounds like polyphenols from plant cell cultures show promise for preventing skin photoaging. These substances offer sun protection by absorbing UV radiation, fighting free radicals, and reducing UV-induced skin damage.

Area of Science:

  • Dermatology and Cosmetology
  • Plant Biotechnology
  • Photobiology

Background:

  • Solar UV irradiation is a primary cause of skin photoaging, affecting molecular pathways and cellular targets.
  • Developing effective, safe, and sustainable topical photoprotective agents remains a challenge for industry.

Purpose of the Study:

  • To propose in vitro methods for preselecting natural photoprotective substances.
  • To identify natural compounds with physical, chemical, and biological photoprotective properties for preventing and rejuvenating photoaged skin.

Main Methods:

  • Development of in vitro assays for preselecting natural photoprotective substances.
  • Evaluation of photostability, phototoxicity, UV absorption, antioxidant capacity, and cellular responses in human keratinocytes.
  • Utilizing meristem plant cell cultures elicited by UV irradiation.

Main Results:

  • Plant-derived secondary metabolites, including phenylpropanoids, flavonoids, and leontopodic acids, demonstrated significant photoprotective potential.
  • Meristem plant cell cultures are a sustainable source of polyphenols with combined photoprotective and antiaging effects.
  • Identified compounds effectively absorb UVA+UVB, reduce free radicals, and mitigate UV-induced cellular damage.

Conclusions:

  • Natural compounds, particularly polyphenols from UV-elicited plant cell cultures, offer a promising strategy for topical photoprotection and skin rejuvenation.
  • The proposed in vitro methods enable efficient preselection of natural photoprotective agents.
  • Sustainable biotechnological approaches can yield effective natural ingredients for cosmetic and pharmaceutical applications.
Keywords:
broadband sunscreenshuman keratinocytesphoto-chemotoxicityphotostabilityplant polyphenolsskin photoagingsolar UVA+UVB

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