Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.

Frontiers in immunology·2025

Same author

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.

Nature communications·2020

Same author

Analysis of 1508 Plasma Samples by Capillary-Flow Data-Independent Acquisition Profiles Proteomics of Weight Loss and Maintenance.

Molecular & cellular proteomics : MCP·2019

Same author

Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome.

Cell·2016

Same author

A Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery.

Journal of proteome research·2015

Same author

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.

Molecular & cellular proteomics : MCP·2015

Same journal

How Much Chirality is Enough?

Chimia·2026

Same journal

Raman Optical Activity (ROA) as an Emerging Standard in Molecular Chirality Measurements - A Perspective.

Chimia·2026

Same journal

Molecular Chirality: From Structure to the Quantum Dynamics of Tunnelling, Parity Violation, a Molecular Quantum Switch and the Possible Astrophysical Detection of Homochirality as a Signature of Extraterrestrial Life.

Chimia·2026

Same journal

Shining Light on Chiral Monolayer-protected Metal Clusters.

Chimia·2026

Same journal

Spin Depolarization Mechanisms in Halide Perovskite Semiconductors.

Chimia·2026

Same journal

New Insights into Circularly Polarized Luminescence from Chromium(III) Spin-Flip Emitters.

Chimia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Next-generation Proteomics from an Industrial Perspective.

Oliver Rinner¹

¹CEO Biognosys AG Wagistrasse 25, CH-8952 Schlieren, Switzerland. oliver.rinner@biognosys.ch.

|June 30, 2017

Summary

This summary is machine-generated.

This article explains proteomics, the study of proteins, focusing on protein expression profiling. It details how to measure protein levels in samples and their changes in response to environmental shifts.

More Related Videos

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Related Experiment Videos

Last Updated: Feb 27, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Area of Science:

Proteomics: The large-scale scientific study of proteins.

Background:

The field of proteomics has evolved from traditional protein purification and analysis.
Modern proteomics heavily relies on mass spectrometry for high-throughput protein quantification.

Purpose of the Study:

This article focuses on protein expression profiling.
It aims to explain how to quantify protein levels within biological samples.
The study also addresses how these protein levels change in response to environmental variations.

Main Methods:

Mass spectrometry is the primary technique discussed for protein quantification.
The article emphasizes highly multiplexed analysis capabilities.

Main Results:

Protein expression profiling provides insights into sample composition.
Quantification of protein level changes reveals responses to environmental stimuli.

Conclusions:

Understanding protein expression is crucial in proteomics research.
Mass spectrometry-based methods enable comprehensive protein analysis.