Unbridle biomedical research from the laboratory cage

Area of Science:

• Biomedical Research
• Animal Welfare Science
• Laboratory Animal Science

Background:

• Biomedical research frequently utilizes captive animals to model human diseases.
• Standard laboratory housing conditions can lead to abnormal biological systems in research animals, potentially compromising study validity.
• There is a growing need to improve the translational relevance of animal models in biomedical research.

Purpose of the Study:

• To highlight the limitations of standard laboratory housing for research animals.
• To advocate for the implementation of more naturalistic and enriching environments for captive animals.
• To emphasize the potential of new technologies for studying freely roaming animals.

Main Methods:

• Review of existing studies on animal models in biomedical research.
• Analysis of findings related to biological abnormalities in standard laboratory housing.
• Consideration of technological advancements enabling the study of freely roaming animals.

Main Results:

• A significant number of studies indicate abnormal biological systems in animals housed in standard laboratory settings.
• Naturalistic environments offering a range of experiences are proposed as a means to improve animal welfare and study relevance.
• Technological progress now permits the observation and study of animals in free-roaming conditions.

Conclusions:

• Biomedical research requires more biologically relevant animal models.
• Implementing enriched or free-roaming environments for research animals is crucial for improving study outcomes.
• Leveraging new technologies to study animals in naturalistic settings is essential for advancing human health research.