Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

97
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
97
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.4K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

4.1K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy.

Journal of medicinal chemistry·2026
Same author

Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors.

Journal of medicinal chemistry·2026
Same author

Discovery and Characterization of Novel IKZF1/3 Glue Degraders against Multiple Hematological Cancer Cell Lines.

Oncology research·2025
Same author

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers.

Journal of medicinal chemistry·2025
Same author

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

Journal of medicinal chemistry·2025
Same author

NLRP3 proteins translocation into nuclei mediates SV40 T-antigen-induced corneal epithelial cell immortalization.

Experimental eye research·2025
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles

Related Experiment Video

Updated: Feb 27, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.9K

Dry Eye Management: Targeting the Ocular Surface Microenvironment.

Xiaobo Zhang1,2,3,4, Vimalin Jeyalatha M5,6,7, Yangluowa Qu8,9,10

  • 1Eye Institute of Xiamen University, Xiamen 361102, China. xiaoboz@xmu.edu.cn.

International Journal of Molecular Sciences
|June 30, 2017
PubMed
Summary
This summary is machine-generated.

Dry eye disease damages the ocular surface. Understanding the ocular surface microenvironment is key to diagnosing and effectively treating dry eye by restoring its natural balance.

Keywords:
dry eyehomeostasismicroenvironmentocular surface

More Related Videos

Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
05:21

Establishment of A Mouse Model of Aqueous Deficiency Dry Eye

Published on: November 1, 2024

1.4K
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
05:00

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

15.7K

Related Experiment Videos

Last Updated: Feb 27, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.9K
Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
05:21

Establishment of A Mouse Model of Aqueous Deficiency Dry Eye

Published on: November 1, 2024

1.4K
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
05:00

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

15.7K

Area of Science:

  • Ophthalmology
  • Ocular Surface Disease
  • Dry Eye Disease Pathophysiology

Background:

  • Dry eye disease encompasses a range of conditions causing ocular surface damage, from mild defects to severe vision-threatening complications.
  • Recent advancements in dry eye treatment have evolved from simple lubrication to more complex strategies including tear secretion stimulation, anti-inflammatory, and immune-regulating therapies.

Purpose of the Study:

  • To introduce and review the concept of the ocular surface microenvironment in the context of dry eye disease.
  • To highlight the role of microenvironment homeostasis in maintaining ocular surface health.
  • To emphasize the importance of evaluating microenvironment changes for diagnosis and management.

Main Methods:

  • Literature review of recent advancements in dry eye pathophysiology and treatment.
  • Conceptual framework development focusing on the ocular surface microenvironment.
  • Analysis of how microenvironment disruption leads to dry eye disease.

Main Results:

  • The ocular surface microenvironment comprises various components crucial for maintaining homeostasis.
  • Disruption of this microenvironment is a central factor in the development of dry eye disease.
  • Comprehensive assessment of microenvironment alterations offers a pathway to improved diagnosis and treatment.

Conclusions:

  • Restoring ocular surface microenvironment homeostasis is the ultimate goal for successful dry eye treatment.
  • Evaluating specific microenvironment components aids in precise diagnosis and timely clinical intervention.
  • The microenvironment concept provides a unified perspective on dry eye pathophysiology and management.