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Adipokines in Liver Cirrhosis
Christa Buechler1, Elisabeth M Haberl2, Lisa Rein-Fischboeck3
1Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany. christa.buechler@klinik.uni-regensburg.de.
International Journal of Molecular Sciences
|June 30, 2017
Summary
Adipokines, proteins from fat tissue, may influence liver fibrosis severity. Studies analyze adipokine levels in cirrhosis patients to understand their role in liver disease progression and complications.
Area of Science:
- Hepatology
- Endocrinology
- Biochemistry
Background:
- Liver fibrosis can advance to cirrhosis, a severe condition impacting liver function.
- Portal hypertension is a key complication of cirrhosis, leading to ascites and bleeding.
- Adipokines, released by adipose tissue, influence liver processes like inflammation and fibrosis.
Purpose of the Study:
- To review the role of adipokines in hepatitis and liver fibrosis.
- To identify adipokines with altered circulating levels in liver cirrhosis patients.
- To explore associations between adipokines and liver function, portal hypertension, and complications.
Main Methods:
- Literature review of studies analyzing adipokines in cirrhotic patients.
- Analysis of adipokine levels in systemic, hepatic, and portal vein blood.
- Examination of adipokine changes after transjugular intrahepatic portosystemic shunt (TIPS) placement.
Main Results:
- Adiponectin shows protective effects against hepatic inflammation and fibrogenesis.
- Leptin acts as a profibrogenic factor in liver disease.
- Circulating adipokine levels vary among different cohorts of liver cirrhosis patients.
Conclusions:
- Adipokines are implicated in modulating the severity of liver cirrhosis.
- Further research is needed to fully elucidate the role of specific adipokines in liver disease.
- Understanding adipokine profiles may offer insights into disease progression and potential therapeutic targets.
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