Genomic testing for localized prostate cancer: where do we go from here?

Area of Science:

• Oncology
• Genomics
• Urology

Background:

• Localized prostate cancer management involves risk stratification.
• Genomic testing provides advanced prognostic information beyond traditional methods.

Purpose of the Study:

• To review current genomic testing options for localized prostate cancer.
• To highlight the utility of these tests in aiding treatment decisions.

Main Methods:

• Review of available genomic tests for localized prostate cancer.
• Analysis of test applications on biopsy and post-prostatectomy tissue.

Main Results:

• Prolaris, OncotypeDx, and Decipher are available genomic tests for localized prostate cancer.
• These tests, utilizing biopsy or radical prostatectomy tissue, predict disease progression, risk of death, or metastasis.
• Decipher also offers insights into cell lineage and radiation sensitivity.

Conclusions:

• Genomic tests provide crucial prognostic risk stratification for localized prostate cancer.
• These advanced tools assist clinicians and patients in making informed treatment decisions.
• The application of genomic testing is expanding for localized prostate cancer management.