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First Cases of Severe Flaccid Paralysis Associated With Enterovirus D68 Infection in Spain, 2015-2016
María Cabrerizo1, Juan Pablo García-Iñiguez, Francina Munell
1From the *Spanish National Poliovirus Laboratory, National Centre for Microbiology, Institute of Health "Carlos III", Madrid, Spain; †Department of Pediatrics and **Department of Microbiology, Miguel Servet Hospital, Zaragoza, Spain; ‡Department of Pediatrics, Vall d'Hebron University Hospital and Autonoma University, Barcelona, Spain; §Department of Pediatrics and §§Department of Preventive Medicine, University Hospital of Vigo (Alvaro Cunqueiro Hospital), Vigo, Pontevedra, Spain; ¶University Hospital Germans Trias i Pujol School of Medicine, Barcelona, Spain; ‖Department of Microbiology, University Hospital of Vigo (Meixoeiro Hospital), Vigo, Spain; ††Department of Microbiology, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Barcelona, Spain; ‡‡Department of Microbiology, Santa Creu i Sant Pau Hospital, Barcelona, Spain; and ¶¶National Centre for Epidemiology, Institute of Health "Carlos III" and CIBERESP, Madrid, Spain.
Abstract:
Enterovirus D68 was known to be the cause of mild to severe respiratory infections, but in the last few years, it has also been associated with myelitis and paralysis. This report describes the first Enterovirus D68 detections in acute flaccid paralysis cases occurring between December 2015 and March 2016 in Spain.
Insights
Enterovirus D68, previously linked to respiratory illness, is now associated with acute flaccid paralysis. This study reports the first detections of Enterovirus D68 in Spanish paralysis cases.
Area of Science:
- Neurology
- Virology
- Infectious Diseases
Background:
- Enterovirus D68 (EV-D68) is a known respiratory pathogen.
- Recent evidence links EV-D68 to neurological complications, including myelitis and paralysis.
- The epidemiology of EV-D68 in relation to neurological disease requires further investigation.
