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The association between gout and cataract risk: A meta-analysis
Chenqi Luo1, Xinyi Chen1, Hongchuan Jin2
1Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Plos One
|June 30, 2017
Summary
Gout is linked to a higher risk of developing age-related cataracts (ARCs), particularly posterior subcapsular and cortical types. Further research is needed to confirm this association and explore the impact of gout medications.
Area of Science:
- Ophthalmology
- Rheumatology
- Epidemiology
Background:
- Gout is a common inflammatory arthritis characterized by hyperuricemia.
- Age-related cataracts (ARCs) are a leading cause of vision impairment globally.
- The potential link between systemic inflammatory conditions and cataract development warrants investigation.
Purpose of the Study:
- To systematically evaluate the association between gout and the risk of developing age-related cataracts.
- To identify specific types of cataracts potentially linked to gout.
Main Methods:
- A meta-analysis was performed on studies identified through PubMed and Web of Science (1991-2017).
- Inclusion criteria focused on studies examining the relationship between gout and cataract risk.
- Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model where heterogeneity was present.
Main Results:
- Six studies (3 cross-sectional, 3 case-control) were included in the meta-analysis.
- Gout was significantly associated with an increased odds of ARCs (OR 1.53, 95% CI 1.27-1.84).
- Subgroup analyses revealed positive associations between gout and posterior subcapsular cataracts (OR 1.69) and cortical cataracts (OR 1.39), but not nuclear cataracts.
Conclusions:
- Current evidence suggests a potential link between gout and an elevated risk of ARCs, specifically PSCs and CCs.
- Further research is recommended to solidify these findings.
- Investigating the influence of gout and its pharmacological treatments on cataractogenesis is crucial.
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