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Updated: Feb 27, 2026
Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI
Published on: October 20, 2023
Hepatic fat quantification using automated six-point Dixon: Comparison with conventional chemical shift based
Kie Shimizu1, Tomohiro Namimoto1, Masataka Nakagawa1
1Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuoku, Kumamoto 860-8556, Japan.
Purpose:
To compare automated six-point Dixon (6-p-Dixon) MRI comparing with dual-echo chemical-shift-imaging (CSI) and CT for hepatic fat fraction in phantoms and clinical study.
Materials And Methods:
Phantoms and fifty-nine patients were examined both MRI and CT for quantitative fat measurements.
Results:
In phantom study, linear regression between fat concentration and 6-p-Dixon showed good agreement. In clinical study, linear regression between 6-p-Dixon and dual-echo CSI showed good agreement. CT attenuation value was strongly correlated with 6-p-Dixon (R2=0.852; P<0.001) and dual-echo CSI (R2=0.812; P<0.001).
Conclusion:
Automated 6-p-Dixon and dual-echo CSI were accurate correlation with CT attenuation value of liver parenchyma. 6-p-Dixon has the potential for automated hepatic fat quantification.
