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Type II Peter's anomaly with histopathological proof: a case report
Rui-Qi Chang1,2,3,4, Yu Du1,2,3,4, Xiang-Jia Zhu5,6,7,8
1Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
BMC Ophthalmology
|July 1, 2017
Summary
This case report details bilateral Peter's anomaly, a rare congenital condition affecting eye development. Histopathological findings offer insights into developmental anomalies contributing to this condition.
Area of Science:
- Ophthalmology
- Developmental Biology
- Genetics
Background:
- Peter's anomaly is a rare congenital anterior segment dysgenesis.
- It is characterized by poor visual outcomes.
- This report focuses on a unique case of bilateral Type II Peter's anomaly.
Observation:
- A 7-year-old boy presented with bilateral central corneal opacity, photophobia, and severe vision reduction since birth.
- Clinical examination revealed iris abnormalities, irregular pupils, and lens adhesion to the cornea.
- The patient had a history of premature birth and mental retardation.
Findings:
- The case involved bilateral Type II Peter's anomaly with pseudophakia in the right eye and amblyopia.
- Intraoperative findings included a vesicle-like structure in the anterior chamber.
- Histopathological examination revealed immature lens and corneal stroma within this structure.
Implications:
- The histopathological features provide potential evidence for developmental anomaly hypotheses in Peter's anomaly.
- Understanding these features may aid in diagnosing and managing this rare condition.
- Further research into the developmental mechanisms is warranted.
Keywords:
AmblyopiaCongenital cataractCorneal leukomaCorneolenticular adhesionHistopathologyPeter’s anomaly
