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Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.

Geena Skariah1, Joseph Seimetz2, Miles Norsworthy3

  • 1Neuroscience Program, University of Illinois-Urbana Champaign, Urbana, IL, 61801, USA.

BMC Biology
|July 1, 2017
PubMed
Summary

Moloney leukemia virus 10 (Mov10) is crucial for mouse brain development, regulating neuronal structure and function. Its absence causes embryonic lethality and impacts brain circuitry, highlighting its role in neurological health.

Keywords:
BrainEmbryonic developmentL1Mov10Neurite outgrowthNeurogenesisRISCRNA helicaseRetrotransposons

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Moloney leukemia virus 10 (Mov10) is an RNA helicase previously studied only in cell lines.
  • Its role in retrotransposon regulation and mRNA access was investigated in the context of the developing mouse brain.
  • Mov10 knockout resulted in early embryonic lethality, indicating its essential function.

Purpose of the Study:

  • To investigate the role of Mov10 in the mouse brain during development.
  • To characterize Mov10's function in neuronal development and brain circuitry.
  • To explore Mov10's potential link to neurological disorders.

Main Methods:

  • Examined Mov10 expression during mouse brain development.
  • Attempted to create Mov10 knockout mice.
  • Analyzed Mov10 binding partners (retroelement RNAs and mRNAs).
  • Assessed effects of Mov10 deficiency on neuronal morphology and behavior.

Main Results:

  • Mov10 expression is elevated in the postnatal murine brain.
  • Mov10 suppresses retroelements and regulates cytoskeletal mRNAs impacting neurite outgrowth.
  • Mov10 deficiency in mice led to reduced dendritic arborization, shortened neurites, anxiety, and increased activity.
  • Mov10, Fmrp, and Ago2 bind a common set of brain mRNAs.

Conclusions:

  • Mov10 is essential for normal neuronal development and brain function.
  • Mov10 regulates RNAs involved in cytoskeleton and neuronal projection.
  • Mov10 is a potential candidate for neurological disorders with cytoarchitectural defects, such as autism and Alzheimer's disease.