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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Cognitive Bias Modification for paranoia (CBM-pa): study protocol for a randomised controlled trial.

Jenny Yiend1, Antonella Trotta2, Christopher Meek2

  • 1Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. jenny.yiend@kcl.ac.uk.

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|July 1, 2017
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Summary

This study tested a new intervention to reduce paranoia in psychosis patients. Cognitive Bias Modification for paranoia (CBM-pa) showed potential feasibility and efficacy for treating persecutory delusions.

Keywords:
Cognitive Bias ModificationComputerised therapyInterpretation biasParanoiaPersecutory delusionsPsychosisRCT

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Area of Science:

  • Psychiatry
  • Cognitive Psychology
  • Clinical Psychology

Background:

  • Persecutory delusions are common in psychosis, affecting 10-15% of the general population.
  • These delusions are often sustained by biased cognitive and emotional processes.
  • Targeted interventions are advancing to address specific symptoms and mechanisms of psychosis.

Purpose of the Study:

  • To test the clinical feasibility of a novel psychological intervention, Cognitive Bias Modification for paranoia (CBM-pa).
  • To reduce paranoia in patients by manipulating biased interpretations toward more adaptive processing.
  • To evaluate CBM-pa's potential as a cost-effective, accessible, and flexible treatment.

Main Methods:

  • A feasibility, double-blind, randomized controlled trial (RCT) involving 60 outpatients with persistent paranoid symptoms.
  • Participants were randomized 50:50 to computerized CBM-pa or a text-reading control.
  • Interventions consisted of one 40-min session weekly for 6 weeks, with assessments at baseline, interim, post-treatment, and 1- and 3-month follow-ups.

Main Results:

  • The primary outcome was the feasibility of the trial design, recruitment rate, and acceptability of the CBM-pa intervention.
  • Secondary outcomes included clinical symptom severity, paranoia levels, interpretation bias, and stress/distress.
  • Preliminary evidence of efficacy was assessed to determine the need for a fully powered RCT.

Conclusions:

  • The CBM-pa study is a pilot to assess feasibility and potential efficacy.
  • If feasible, this intervention could offer a novel approach to managing persecutory delusions.
  • Successful feasibility may lead to a larger randomized controlled trial for broader clinical application.