Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

343
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
343
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model01:14

Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model

51
The link model is a fundamental pharmacokinetic-pharmacodynamic (PK–PD) approach to account for delayed drug responses when the observed effect does not immediately correlate with the drug's plasma concentration peak. This delay is mathematically addressed by introducing an effect compartment concentration, Ce, which is kinetically linked to the plasma concentration, Cp, via a first-order rate constant, ke0. The linkage allows for a more accurate prediction of drug effects over time. A...
51
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

81
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
81
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

299
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
299
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

669
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
669
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

473
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
473

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulating digital surgery to balance safety and innovation: a SAGES white paper.

Surgical endoscopy·2026
Same author

Video-based assessment tool for workflow analysis in minimally invasive colorectal surgery: expert consensus-based development and multicentre validation of ColoWorkflow.

BJS open·2026
Same author

Single-port robotic colorectal surgery: a scoping review of outcome reporting and future directions for standardisation.

Journal of robotic surgery·2026
Same author

SAGES 2025 guidelines for fluorescence image-guided gastrointestinal surgery using indocyanine green.

Surgical endoscopy·2025
Same author

SAGES 2025 systematic review and meta-analysis for fluorescence image-guided gastrointestinal surgery using indocyanine green.

Surgical endoscopy·2025
Same author

Artificial intelligence-assisted video analysis for evaluating ergonomic strain in robotic surgeons: a pilot study from the SAGES ergonomics task force.

Surgical endoscopy·2025

Related Experiment Video

Updated: Feb 27, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

9.3K

Predicting delayed discharge in a multimodal Enhanced Recovery Pathway.

Deborah S Keller1, Irlna Tantchou2, Juan R Flores-Gonzalez3

  • 1Division of Colorectal Surgery, Department of Surgery, Baylor University Medical Center, Dallas, TX, USA.

American Journal of Surgery
|July 1, 2017
PubMed
Summary

Preoperative anxiety, chronic pain, and intraoperative conversion are linked to delayed discharge in colorectal surgery patients despite Enhanced Recovery Pathways (ERP). Addressing these factors can improve patient outcomes and reduce prolonged hospital stays.

Keywords:
Enhanced recovery after surgeryHealthcare outcomesLaparoscopic colorectal surgeryLength of stayMinimally invasive colorectal surgeryReadmission

More Related Videos

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion
08:13

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Published on: January 20, 2019

7.2K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

22.1K

Related Experiment Videos

Last Updated: Feb 27, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

9.3K
Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion
08:13

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Published on: January 20, 2019

7.2K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

22.1K

Area of Science:

  • Colorectal Surgery
  • Surgical Outcomes
  • Patient Recovery Pathways

Background:

  • Enhanced Recovery Pathways (ERP) aim to optimize patient recovery and reduce length of stay (LOS) after surgery.
  • Despite ERP implementation, some patients experience unexpectedly prolonged LOS, necessitating identification of associated factors.

Purpose of the Study:

  • To identify patient and procedural variables linked to delayed discharge in minimally invasive colorectal resections within an established ERP.
  • To understand factors contributing to ERP failure, defined as LOS ≥5 days.

Main Methods:

  • A retrospective review of a divisional database for minimally invasive colorectal resections (August 2013 - July 2015).
  • Patients were categorized into ERP success (LOS <5 days) or failure (LOS ≥5 days).
  • Logistic regression analysis was used to determine variables predicting ERP failure.

Main Results:

  • 45 of 274 patients (16.4%) experienced ERP failure.
  • Factors associated with ERP failure included preoperative anxiety, chronic pain, prior abdominal surgery, and chemoradiation.
  • Intraoperative factors like conversion to open surgery and blood transfusions were significantly higher in the failure group.
  • Anxiety (OR 2.28), chronic pain (OR 10.03), and intraoperative conversion (OR 8.02) were independently associated with delayed discharge.

Conclusions:

  • Preoperative patient factors (anxiety, chronic pain) and intraoperative procedural factors (conversion) are significantly associated with delayed discharge in colorectal surgery.
  • Prospective patient preparation and practice modifications addressing procedural elements and ERP adherence can enhance postoperative outcomes.