Related Experiment Video

Updated: Feb 27, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.2K

Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies

Yoshifumi Itoh1

  • 1Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

Progress in Molecular Biology and Translational Science
|July 1, 2017
PubMed

Insights

Rheumatoid arthritis (RA) involves joint tissue destruction driven by metalloproteinases (MPs). Inhibitors targeting these MPs show promise as potential treatments for RA.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a systemic inflammatory disease causing joint tissue destruction.
  • Cartilage and bone degradation in RA is linked to metalloproteinases (MPs).
  • MPs, including matrix metalloproteinases and ADAMs, are implicated in RA pathogenesis.

Purpose of the Study:

  • To review recent findings on metalloproteinases (MPs) in rheumatoid arthritis (RA).
  • To explore the potential of MPs as therapeutic targets for RA treatment.

Main Methods:

  • Literature review of recent reports on MPs in RA.
  • Analysis of the role of specific metalloproteinases in RA pathogenesis.
  • Evaluation of metalloproteinase inhibitors as potential RA therapeutics.

Main Results:

  • Metalloproteinases (MPs) are key mediators of cartilage and bone destruction in RA.
  • Specific MPs, including matrix metalloproteinases and ADAMs, contribute to RA pathology.
  • Development of selective MP inhibitors presents a viable therapeutic strategy.

Conclusions:

  • Metalloproteinases are critical targets for RA treatment.
  • Targeting MPs offers a promising avenue for developing novel RA therapies.
  • Further research into MP inhibitors is warranted for RA management.
Keywords:
ADAMADAMTSAnti-TNFCartilageInflammationMMPsMetalloproteinasesRheumatoid arthritis

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.3K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

9.2K

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.5K
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
420
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.4K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.5K