Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Inflammatory Response01:28

Inflammatory Response

17.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.5K
Inflammation01:38

Inflammation

62.8K
Overview
62.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.6K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.6K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

13.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

815
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
815

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Hemoperitoneum detected by peritoneal dialysis as presenting symptom of cytomegalovirus-associated colitis: a case report.

BMC nephrology·2026
Same author

Predicting Macrophage Spatial Localization from Single-Cell Transcriptomes to Uncover Disease Mechanisms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Pyelonephritis decreases serum cholesterol and mitigates atherosclerosis severity despite systemic inflammation.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q.

Kidney international·2026
Same author

Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice.

Physiological reports·2025

Related Experiment Video

Updated: Feb 27, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

35.4K

Interleukin 17A in atherosclerosis - Regulation and pathophysiologic effector function.

Johannes Nordlohne1, Sibylle von Vietinghoff1

  • 1Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Cytokine
|July 1, 2017
PubMed
Summary

Interleukin-17A (IL-17A) is implicated in atherosclerosis, influencing leukocyte recruitment and plaque development. Its role is complex, potentially offering therapeutic targets but with varied effects on plaque stability.

Keywords:
Apoe(−/−) miceAtherosclerosisInterleukin-17MacrophageVascular inflammation

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

35.6K

Related Experiment Videos

Last Updated: Feb 27, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

35.4K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

35.6K

Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Inflammation Research

Background:

  • Interleukin-17A (IL-17A) is a key cytokine in T cell responses, produced by innate and adaptive leukocytes.
  • Elevated IL-17A levels and expression in specific T cell subsets are observed in atherosclerosis.
  • Factors associated with cardiovascular risk, such as lipids and glucose, influence IL-17A expression.

Purpose of the Study:

  • To review current data on the IL-17A pathway in experimental and clinical atherosclerosis.
  • To explore the multifaceted role of IL-17A in atherogenesis and its potential as a therapeutic target.

Main Methods:

  • Review of experimental atherosclerosis models and clinical data.
  • Analysis of cytokine expression, leukocyte infiltration, and plaque characteristics.
  • Examination of IL-17A receptor expression and downstream effects.

Main Results:

  • IL-17A promotes leukocyte (neutrophil, monocyte, macrophage) recruitment in atherosclerosis.
  • IL-17A affects endothelial function, fibrous cap formation, and vascular relaxation.
  • Anti-IL-17A agents show benign cardiovascular side effect profiles in current clinical use.

Conclusions:

  • IL-17A is a differential regulator of atherosclerosis, with complex and potentially contradictory effects on plaque size and stability.
  • Modulation of the IL-17A pathway may offer therapeutic benefits but requires careful consideration of patient-specific responses.