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Appendiceal Mucinous Neoplasms: Diagnosis and Management
Walid L Shaib1,2, Rita Assi3, Ali Shamseddine3
1Department of Hematology and Oncology, Atlanta, Georgia, USA wshaib@emory.edu.
The Oncologist
|July 1, 2017
Summary
Appendiceal mucinous neoplasms (AMNs) are rare tumors with varied treatments. This review guides management based on stage and histology, recommending surgery and HIPEC for advanced cases.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Appendiceal mucinous neoplasms (AMNs) represent a rare and heterogeneous group of tumors with increasing incidence.
- Current clinical management of AMNs is challenging due to a lack of consensus on classification and treatment guidelines.
Purpose of the Study:
- To review existing literature on treatment modalities for appendiceal mucinous neoplasms (AMNs).
- To provide guidance for the clinical management of AMNs based on current data and controversies.
Main Methods:
- A comprehensive PubMed search was conducted in February 2016 using relevant keywords.
- English-language publications, including American Society of Clinical Oncology meeting abstracts, were reviewed.
Main Results:
- Summarized current data on AMN classification, clinical presentation, and molecular alterations.
- Reviewed treatment outcomes for cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and systemic chemotherapy.
Conclusions:
- Treatment for AMNs depends on tumor stage and histology.
- Low-grade AMNs are managed with surgery or debulking and HIPEC for advanced disease.
- High-grade AMNs require further trials; options include surgery, HIPEC, and chemotherapy, with a need for novel therapies targeting molecular profiles.
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