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Related Concept Videos

Necrosis01:16

Necrosis

6.9K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
493
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

634
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
634
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

647
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
647
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

612
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
612
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

291
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
291

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Updated: Feb 27, 2026

Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
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Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis

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Necrotising coronaritis with fatal outcome.

Lisa Schweizer1, Nadja Fischer2, Thomas Fehr1

  • 1Department of Internal Medicine, Kantonsspital Graubunden, Chur, Switzerland.

BMJ Case Reports
|July 1, 2017
PubMed
Summary

A rare case of diffuse necrotising coronary vasculitis caused a 56-year-old woman's fatal myocardial infarction and cardiac arrest. This vasculitis led to ischaemic heart disease, mimicking typical acute coronary syndrome.

Keywords:
Interventional CardiologyIschaemic Heart DiseasePathologyVasculitis

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Area of Science:

  • Cardiology
  • Pathology
  • Immunology

Background:

  • Acute coronary syndrome (ACS) with ST-segment elevation myocardial infarction (STEMI) is a common emergency.
  • Coronary angiography is standard for diagnosing obstructive coronary artery disease (CAD).
  • Cardiac MRI is valuable for assessing myocardial viability and damage.

Observation:

  • A 56-year-old woman presented with STEMI symptoms, but angiography excluded obstructive CAD.
  • Cardiac MRI revealed transmural necrosis and microvascular obstruction, suggesting ischaemic heart disease.
  • The patient experienced sudden cardiac arrest due to pulseless electrical activity within 48 hours.

Findings:

  • Autopsy identified myocardial perforation and pericardial laceration, attributed to chest compressions.
  • Histology revealed diffuse necrotising coronary vasculitis as the underlying cause of myocardial necrosis.
  • This rare vasculitis mimicked typical ischaemic heart disease presentation.

Implications:

  • Diffuse necrotising coronary vasculitis is a rare but critical differential diagnosis for ischaemic heart disease.
  • Early recognition of vasculitis may alter patient management and prognosis.
  • This case highlights the importance of comprehensive autopsy in unexplained cardiac events.