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Related Concept Videos

Cholesterol: Significance and Regulation01:29

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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Related Experiment Video

Updated: Feb 27, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Cholesterol: the debate should be terminated.

David G Nathan1,2

  • 1Pediatric Blood and Cancer Center, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; david_nathan@dfci.harvard.edu.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 1, 2017
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Summary

This perspective argues that certain aspects of the cholesterol homeostasis debate are overstated. The author believes the ongoing discussion regarding cholesterol should be concluded.

Keywords:
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Area of Science:

  • Biochemistry
  • Physiology

Background:

  • Cholesterol homeostasis is a complex physiological process.
  • Ongoing debates exist regarding the interpretation of cholesterol levels and their clinical significance.

Purpose of the Study:

  • To offer personal perspectives on cholesterol homeostasis.
  • To argue that specific facets of the cholesterol debate have been exaggerated.

Main Methods:

  • This study is based on the author's personal viewpoints and reflections.
  • It involves a critical analysis of existing perspectives on cholesterol.

Main Results:

  • Certain elements of the cholesterol homeostasis debate are considered overstated by the author.
  • The author posits that the debate surrounding cholesterol should be terminated.

Conclusions:

  • The author's perspective suggests a need to re-evaluate the current discourse on cholesterol.
  • A call to conclude the debate implies a potential consensus or a shift in focus is warranted.