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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Related Experiment Video

Updated: Feb 27, 2026

Control of Eating Behavior Using a Novel Feedback System
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Brain stimulation in obesity.

C H Göbel1, V M Tronnier2, T F Münte1,3

  • 1Department of Neurology, University of Lübeck, Lübeck, Germany.

International Journal of Obesity (2005)
|July 1, 2017
PubMed
Summary
This summary is machine-generated.

Neuromodulation offers promising new obesity treatments by targeting brain circuits. While non-invasive methods require more research, deep brain stimulation shows potential for treatment-resistant obesity.

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Area of Science:

  • Neuroscience
  • Metabolic Disorders
  • Medical Technology

Background:

  • Obesity is a global epidemic with limited treatment efficacy.
  • Current therapies like behavioral, pharmacological, and bariatric surgery have significant limitations.
  • Novel therapeutic strategies are crucial for managing severe and treatment-resistant obesity.

Purpose of the Study:

  • To review conceptual models of obesity, focusing on the 'food addiction' model.
  • To explore brain stimulation techniques as potential therapies for obesity.
  • To evaluate the efficacy and readiness of neuromodulatory approaches for clinical use.

Main Methods:

  • Review of current literature on obesity conceptual models.
  • Analysis of non-invasive brain stimulation techniques: transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcutaneous vagus nerve stimulation (VNS).
  • Evaluation of invasive brain stimulation techniques: deep brain stimulation and invasive VNS.

Main Results:

  • Neuromodulation targets specific brain structures involved in obesity pathophysiology.
  • Non-invasive techniques (TMS, tDCS, transcutaneous VNS) require further investigation for clinical application.
  • Deep brain stimulation shows promise as an effective therapy for treatment-resistant obesity.

Conclusions:

  • Neuromodulatory approaches represent a promising avenue for obesity treatment.
  • Further research is needed for non-invasive brain stimulation techniques.
  • Deep brain stimulation may offer a viable solution for patients with severe, treatment-resistant obesity.